GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7631605 | 1 | rs6789043 | chr3:37025867 | LRRFIP2 | chr3:37094117-37217851:- | 0.5 | 13.73 | 2.16E-36 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs1552244 | 1 | rs6789156 | chr3:10124120 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.23 | 2.8E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6789156 | chr3:10124120 | VHL | chr3:10183319-10193744:+ | -0.17 | -3.91 | 0.000106 | Alzheimer's disease |
| THCA | cis | rs9815354 | 1 | rs6789260 | chr3:41776350 | ULK4 | chr3:41288091-42003660:- | 1.02 | 17.78 | 1.21E-54 | Diastolic blood pressure |
| THCA | cis | rs10935120 | 1 | rs6790466 | chr3:134197740 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.64 | 8.41E-32 | Height |
| THCA | cis | rs10935120 | 1 | rs6790466 | chr3:134197740 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.35 | 4.99E-10 | Height |
| THCA | cis | rs9815354 | 1 | rs6790732 | chr3:41864872 | ULK4 | chr3:41288091-42003660:- | 1.1 | 21.32 | 2.24E-71 | Diastolic blood pressure |
| THCA | cis | rs9815354 | 1 | rs6791806 | chr3:41889995 | ULK4 | chr3:41288091-42003660:- | 1.09 | 20.95 | 1.23E-69 | Diastolic blood pressure |
| THCA | cis | rs1552244 | 1 | rs6791810 | chr3:10124444 | C3orf10 | chr3:10157333-10168873:+ | 0.19 | 4.13 | 4.31E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6791810 | chr3:10124444 | VHL | chr3:10183319-10193744:+ | 0.19 | 4.39 | 1.42E-5 | Alzheimer's disease |
| THCA | cis | rs6805251 | 1 | rs6792572 | chr3:119636096 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.81 | 2.06E-6 | HDL cholesterol |
| THCA | cis | rs7608910 | 1 | rs67927699 | chr2:61187415 | AHSA2 | chr2:61404553-61414058:+ | -0.13 | -4.86 | 1.56E-6 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs7608910 | 1 | rs67927699 | chr2:61187415 | C2orf74 | chr2:61372243-61391964:+ | 0.5 | 9.67 | 2.46E-20 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs6793295 | 1 | rs6793295 | chr3:169518455 | LRRC34 | chr3:169511266-169530720:- | -0.24 | -4.51 | 8.02E-6 | Multiple myeloma and monoclonal gammopathy;Interstitial lung disease |
| THCA | cis | rs1552244 | 1 | rs6793396 | chr3:10110927 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.34 | 1.71E-5 | Alzheimer's disease |